He first began to work on comics in 1941 on the 3rd issue of Captain America.
Entered the comic book scene at 17 as assistant editor for the Timely comics group. In 1942, he was promoted to editor.
Daughter is model/actress Joan Celia J.C. Lee (b. 1950). His other daughter, Jan Lee, died shortly after birth (1953).
He is credited as creating the Marvel Comics characters in the 1960s which introduced more complex characterizations for super-heroes. He also is credited for popularizing continuity to give the various series a sense of narrative flow and an interrelated common world for the characters. However, since the "plot first" writing method he used meant that the artists he collaborated with, especially Jack Kirby and Steve Ditko, served as essentially co-writers, the matter who truly deserves the credit for the creations from such collaborations is a matter of vigorous debate.
Judy Garland's daughter, Lorna Luft, lived with Lee and his family for a period of time while her mother was in rehab in the 1960s. Stan's daughter, J.C. Lee, and Luft were friends and Lorna stayed with the family for about a month until she went to California to live with her father.
His 3 most famous comic book creations are: Fantastic Four (Debut November 1961), the Incredible Hulk (Debut May 1962) and the Amazing Spiderman (Debut August 1962 in 'Amazing Fantasy' # 15).
Disliked the 1970s live-action Spiderman TV series (for which he was a script consultant), deeming it "too juvenile." He also felt that Spiderman was being treated on the show as a "cardboard character."
Apart from his participation in the creation of the classic Marvel Comics characters, he also helped weaken censorship in the mainstream comics field. This happened when, after a formal request by the United States Department of Health, Education and Welfare, he decided to do a story about the problem of drug abuse. The story he wrote in 1971 for "The Amazing Spider-Man" concerned Peter Parker's friend Harry Osborne having a bad trip on LSD and nearly dying from it. The Comics Code Authority declared that they would not give their seal of approval to the three-issue arc on the grounds that the code, which was notorious for being draconian, would not allow the depiction of drug use even when it is portrayed negatively. Confident that the original government request would give him credibility and with the support of his publisher, Martin Goodman, Lee decided to defy the CCA and published the story as is without the seal and received healthy sales and a positive public reaction for his efforts in portraying the social problem. Soon after, the CCA changed their rules to allow for anti-drug messages in comics.
1972 becomes publisher and editorial director of Marvel
He was a juror in a dream sequence in The Trial of the Incredible Hulk (1989) (TV).
Has it written into his contract that he appears in any movie based upon a Marvel character that he is credited with. So far he has appeared as the Hot Dog Vendor in X-Men (2000), Man in Fair in Spider-Man (2002), Old Man at Crossing in Daredevil (2003), Security Guard in Hulk (2003), Man Dodging Debris in Spider-Man 2 (2004), Willie Lumpkin in Fantastic Four (2005), Waterhose Man in X-Men: The Last Stand (2006), Man in Times Square in Spider-Man 3 (2007), Rejected Wedding Guest in 4: Rise of the Silver Surfer (2007), the man whom Tony Stark mistakes for Hugh Hefner in Iron Man (2008) and an uncredited appearance as the man who drinks the soft drink contaminated with Bruce Banner's blood in The Incredible Hulk (2008). The only one he has not appeared in was X2 (2003). Captain America: The First Avenger (2011), where he appears as a US Army general, is a partial exception; he did not create the character, but he created the character's signature move of throwing his shield in a early text story and was at least partially responsible for successfully reviving him in the 1960s as member of the Avengers.
Along with Lou Ferrigno, he is one of only two actors to appear in both Hulk (2003) and The Incredible Hulk (2008).
He has worked with Chris Evans on four different films: Fantastic Four (2005), 4: Rise of the Silver Surfer (2007), Captain America: The First Avenger (2011) and The Avengers (2012).
He was awarded the 2008 American National Medal of the Arts for his services to comic books and production.
Will be honored with the Visual Effects Society's Lifetime Achievement Award [October 19, 2011].