Attended the Lehman College in New York City in 1971, where he got the Bachelor of Fine Arts degree in Theatre.
Attended the University of Minnesota from fall 1971 to spring 1973. On July 20, 1973, he graduated with his then new degree of Master of Fine Arts.
His children, with Opal Perlman, are Blake Perlman (b. 1984) and Brandon Avery Perlman (b. 1990).
Was ranked in Star Magazine's Reader's Poll - Best Dramatic Actor as Vincent in "Beauty and the Beast" (1987).
Was friends with Sammy Davis Jr.. They met at the Golden Globe Awards in the late 1980s, apparently Davis was a huge "Beauty and the Beast" (1987) fan and had seen every single episode.
His favorite episode of "Beauty and the Beast" (1987) is "Happy Life".
Good friends with former "Beauty and the Beast" (1987) co-star Linda Hamilton. They reunited in the theatre play "Lover Letters" (1991) and in the post-Vietnam War drama Missing in America (2005).
Was offered promotional advertisements as Vincent, his character from the television series "Beauty and the Beast" (1987), but he refused, stating that the character was not there to be exploited.
Was ranked in US Magazine's "20 Who Turned us on" list. [December 26, 1988]
Was ranked in US Magazine's First Annual Reader's Poll - Third runner-up for Best Dramatic Actor as Vincent in "Beauty and the Beast" (1987). 
Voiced the mutant villain Clayface on "Batman" (1992), a character who, ironically, was a disfigured actor, then voiced the villain Slade on "Teen Titans" (2003), and also did the voice of the Hulk/Bruce Banner twice in two separate series, one for a guest spot on "Fantastic Four" (1994) and one for a guest spot on "Iron Man" (1994), in addition to providing the voice of Orion for "Justice League" (2001). He then played the comic book character Hellboy in Hellboy (2004). He went to portray Batman in Justice League Heroes (2006) (VG).
Is well known for his extensive body of work with acting under prosthetic and has given many actors, like Armin Shimerman ("Star Trek: Deep Space Nine" (1993)) and Michael Chiklis (Fantastic Four (2005)), advice on how to emote effectively under full-head prosthetic appliances.
His favorite movie is Nobody's Fool (1994).
Does not speak French and was the only American on set of the French film La cité des enfants perdus (1995). But he learned all of his lines, and delivered them flawlessly.
Said in his audio commentary for La cité des enfants perdus (1995), that of all the things his characters have done in films, his most hated action was when his character, One, attacked Miette under the influence of the evil Octopus Sisters' drug.
His characters are frequently seen smoking cigars (The Last Supper (1995), Happy, Texas (1999), Price of Glory (2000), Night Class (2001), Hellboy (2004), et cetera). Perlman is an avid cigar smoker in real life.
Frequent voice collaborator with fellow voice-actor Keith David. Computer games: Fallout: A Post-Nuclear Role-Playing Game (1997) (VG), Lords of Everquest (2003) (VG), Halo 2 (2004) (VG), Halo 3 (2007) (VG). Animated series: "Aladdin" (1994), "Fantastic Four" (1994), "Justice League" (2001), "Teen Titans" (2003). And they have both had a guest appearance on the television series "The Outer Limits" (1995).
Worked on the Acadamy Award winning short film Two Soldiers (2003) for free as a favor to writer/director Aaron Schneider.
Upon meeting to discuss Hellboy (2004), creator Mike Mignola and director Guillermo del Toro decided to reveal to each other their choice for the lead role. They both said at the same time, Ron Perlman. Revolutions studio wanted a bigger name like Vin Diesel to play the title role, but del Toro fought for Perlman to get the role, and in the end, he did.
To prepare for his role in Hellboy (2004), he read all the Hellboy comics and worked out three hours a day, five to seven days a week. He also worked out while shooting, every day he had off from filming, he would work out.
Broke a rib while filming the subway scenes in Hellboy (2004). He jumped onto a train that was coming towards him.
Was presented with the Acting Award of Excellence at the Big Bear Lake International Film Festival [September 18th, 2004].
Was considered for the role of Uncle Dave in Postal (2007), before Dave Foley was cast.
With the creation of Hellboy II: The Golden Army (2008), at age 58, he became the oldest actor ever to play a main superhero.
Was offered the role of Piccolo in Dragonball Evolution (2009), but turned it down to work on Hellboy II: The Golden Army (2008) instead.
Producers Lawrence Gordon and Lloyd Levin tried hard for Perlman to get cast as Edward Blake aka The Comedian in Watchmen (2009).
Started his own film production company called "Wing and a Prayer" (2010).
Wrote a script some years ago entitled Wooden Lake which he was also going to direct, but as of this date, it has not gone into production (2011).
Was up for a role in The Hobbit: An Unexpected Journey (2012) when Guillermo del Toro was at the helm, but as pre-production was prolonged again and again, del Toro left and so did Perlman.