Was one of the nine original members of the 1980s "brat pack", along with Judd Nelson, Mare Winningham, Anthony Michael Hall, Demi Moore, Ally Sheedy, Molly Ringwald, Emilio Estevez and Andrew McCarthy.
One of the select few to be nominated for and subsequently "win" a Razzie Award and then not get another nomination again. Lowe "won" the 1986 Worst Supporting Actor Razzie for his performance in St. Elmo's Fire (1985).
Mike Myers is known to have resurrected Rob's acting career. He and Rob became close friends while filming Wayne's World (1992). Myers gave him an unbilled role in Austin Powers: International Man of Mystery (1997) (although the scene was deleted in editing) and gave him a role as the young Number Two in Austin Powers: The Spy Who Shagged Me (1999).
Father of Edward Matthew Lowe (b. 1993) and John Owen Lowe (b. 1995)
Lost out for the role in Titanic (1997) which went to Billy Zane.
Impersonated Robert Wagner's voice for the young Number Two in Austin Powers: The Spy Who Shagged Me (1999).
Has the dubious distinction of having left a successful TV series ("The West Wing" (1999)), to having two failed TV series within a year ("The Lyon's Den" (2003), "Dr. Vegas" (2004)), both of which were canceled before running their full season.
8/02: Quit the series "The West Wing" (1999). Reports vary as to why, but it seems to have been a combination of salary dispute and screen-time dispute (the character he plays got less focus on the show in more recent episodes). He will appear in the first 16 episodes of the next season, though.
2000: Voted one of the 50 Most Beautiful People in the World by People magazine.
2003: Helped in the election of Arnold Schwarzenegger as Governor of California.
Was considered for the role of Dr. Derek Shepard on "Grey's Anatomy" (2005).
Sold his six-bedroom house in Montecito, California for $7.6 million. 
In 2011, Lowe told USA Today that if he didn't dye his hair, it would be entirely grey. He said he went grey at age 24.