Graduated from USM in 1977.
Two daughters Josie Lynn (b. 1988 - wife Brooke Adams' adopted daughter prior to marriage, whom Tony later adopted), and Sophie (b. 1993), adopted by the couple after they married.
Has worked both with the Coen Brothers (Barton Fink (1991), The Man Who Wasn't There (2001)) and their former cinematographer, Barry Sonnenfeld (Addams Family Values (1993), Men in Black (1997), Men in Black II (2002)).
Was nominated for Broadway's 1992 Tony Award as Best Actor (Featured Role - Play) for Herb Gardner's "Conversations with My Father."
In 2005, upon winning his second Emmy for "Monk" (2002), he told his fellow nominees that "there's always next year". Ironically, Shalhoub was the only one of the five actors to be nominated the next year.
Keynote speaker at the University of Southern Maine graduation in 2003, his alma mater
When Shalhoub won the Emmy in 2003 for his leading role of detective Adrian Monk, he dedicated the award to his nephew, 34-year-old Gregg Gensler of Green Bay, who died a day earlier.
Nominated for a 2009 Grammy Award for Best Spoken Word Album for Children for "The Cricket in Times Square".