Starred as Sonya in the Sydney Theatre Company's 1992 Production of Anton Chekhov's "Uncle Vanya".
Dropped out of Australia's NIDA (National Institute of Dramatic Arts) in order to make her first film Spotswood (1992).
Gained 40 pounds in 7 weeks for Muriel's Wedding (1994) with the help of a dietitian.
Performs "Throw Your Arms Around Me", "Don't Dream It Over" and "Stand By Me" in the film "Cosi" 1996.
Was romantically linked to actor Jonathan Rhys Meyers while the pair played a couple in Velvet Goldmine (1998).
Played the mother for both Haley Joel Osment and Abigail Breslin in their Oscar nominated roles (The Sixth Sense (1999) and Little Miss Sunshine (2006)).
She has shaved her head five times. Only once for a film though.8 ½ Women (1999).
Nominated for a 2000 Tony Award for her performance as "Queenie" in Michael John LaChiusa's musical "The Wild Party" on Broadway.
Though she vowed not to gain any more weight for movie roles, director Curtis Hanson convinced her to gain twenty-five pounds for her role in In Her Shoes (2005). She believed it was important to her character's personality.
Is only 11 years older than Paul Dano, who plays her son in Little Miss Sunshine (2006).
Member of the jury at the Cannes Film Festival in 2007.
Strenuously campaigned for the role of Mrs. Lovett in Sweeney Todd: The Demon Barber of Fleet Street (2007) but ultimately lost it to Helena Bonham Carter.
Gave birth to her daughter, Sage Florence, by her husband David Galafassi, on 9 January 2008.
Returned to work 9 months after giving birth to her daughter Sage in order to begin filming Mary and Max (2009).
Was 5 months pregnant with her son Arlo when she completed filming on the third series of "United States of Tara" (2009).
Gave birth to her son Arlo Robert Galafassi, with husband Dave Galafassi, in Australia (22 April 2011).
Returned to work 3 months after giving birth to her son Arlo to begin filming Mental (2012).