Was a Go-Go dancer in the seminal rock-and-roll movie The T.A.M.I. Show (1964) (V).
The "Assignment: Earth" episode of "Star Trek" (1966), in which Garr plays a ditsy secretary, was written as the springboard for a spin-off series. The new series was to feature more adventures of Roberta Lincoln (Garr) and Gary Seven (Robert Lansing), but it never came about.
Steven Spielberg cast her in Close Encounters of the Third Kind (1977) after seeing her work on a coffee commercial.
Attended CSU Northridge along with her Close Encounters of the Third Kind (1977) co-star, Richard Dreyfuss.
Continues to work despite the fact that she is battling multiple sclerosis, first diagnosed in 1983.
Biography in: "Who's Who in Comedy" by Ronald L. Smith, pg. 177-178. New York: Facts on File, 1992. ISBN 0816023387
Daughter, Molly O'Neill, was born in November 1993. Her marriage to John O'Neil Keenan took place on the day their adopted daughter Molly was born.
Was the winner on a celebrity edition of "Weakest Link" (2001).
Recovering from a brain aneurysm, suffered on December 21, 2006.