Daughter and namesake of fashion editor Sally Kirkland. Her mother was fashion editor at first Vogue and later Life magazines. She was the only fashion editor at Life Magazine during its history (1944 - 1969). She is legendary for putting Grace Kelly, Audrey Hepburn, Faye Dunaway and Jacqueline Kennedy on the magazine's cover, making them fashion icons.
Began her career off-Broadway circa 1962.
She was the first actress to appear nude in a legitimate stage play, in the 1968 Off-Broadway premiere of "Sweet Eros" by Terrence McNally.
Famously appeared fully nude, whilst riding bareback astride a large hog to illustrate Tom O'Horgan's 1969 film Futz (1969) on the cover of Al Goldstein's Screw magazine.
Turned down the role of "Helen Buckman" in Ron Howard's film Parenthood (1989). Dianne Wiest was cast in the role and received an Academy Award nomination for her work in the film.
In a TV interview, she reported that she used money from her role in Edtv (1999) to have her breast implants removed.