Chosen with the first pick of the NFL draft by the Indianapolis Colts. 
Had four pairs of hightop black shoes made which he planned to wear in the 15 September 2002 game as a tribute to Johnny Unitas. But the NFL threatened to slap Manning with a $25,000 fine if he wore the shoes. Further, it declared only the Baltimore Ravens would have the sole right to honor Unitas with a patch or armband on their uniforms that Sunday.
NFL's co-MVP during the regular season, splitting the award with the Tennessee Titans' Steve McNair. 
Broke the record set by Dan Marino for most regular-season touchdown passes with 49. [27 December 2004]
He and younger brother Eli Manning made NFL history as the first time two brothers who play starting quarterback played against one another. [September 10, 2006]
Led the Indianapolis Colts to their first NFL championship since the 1970 season, to beat the Chicago Bears 29-17 in Super Bowl XLI. Was named Super Bowl MVP. 
Was in the audience, and was on video cheering, when brother Eli Manning led The New York Giants to their Super Bowl XLII victory.