Skipped school at 14 to audition for Milos Forman's Valmont (1989). Although he could ride and fence, at the time he had acted only in school productions. His head shot/resume was a picture from "Our Town" with his other school roles listed on the back. Needless to say, he didn't get the part.
His least favorite scene on "ER" (1994) was mouth-to-mouth resuscitation of a dog; his alltime favorite the Emmy-nominated scene where he stood in a dark room reading to legendary actor and acting coach Sanford Meisner.
September 2004: Announced that he's leaving "ER" (1994) after 10 years to make room for the upcoming generation.
Went on stage and gave a speech at MacWorld computer trade show posing as Apple Computer interim chief Steve Jobs. Jobs invited Wyle for this joke after seeing him in Pirates of Silicon Valley (1999) (TV). [July 1999]
Announced his engagement to makeup artist Tracy Warbin [March 1999]
Bought Bo Derek's ranch in Santa Ynez Valley, California. [June 1999]
November 9, 2002: his wife Tracy Warbin gave birth to son Owen Strausser Wyle in a Los Angeles area hospital.
His wife, Tracy Warbin, gave birth to a girl, Auden Wyle, in Los Angeles, weighing in at 7lb. 7oz. on October 15, 2005.
Seperated from wife Tracy Warbin in late October 2009.
His representative confirmed in January 2010 that he and his wife Tracy Warbin have been separated since October 2009.