Good friends with "ER" (1994) costar, Goran Visnjic.
Appeared in Vibe magazine for the article "Can't A Brother Get No Love." (August 1999 issue).
Was the first choice to play Quincy McCall in Love & Basketball (2000), but had to drop out due to a schedule conflict and was replaced by Omar Epps.
Is mentioned in Eminem's song "Lose Yourself." The song is part of the 8 Mile (2002) soundtrack. Phifer and Eminem both starred in this movie.
Along with the Pennsylvania-based charity organization, The Vine Group, he donated over $100,000 in scholarships, books and computers to Ibadan, Nigeria, where the Mekhi Phifer Education Center will open in 2005 to help poor children get an education.
Engaged to director assistant Onanong Souratha on May 9, 2007.
Son, Mekhi Thira Phifer, Jr., born 30 October 2007. Mother is fiancée Onanong Souratha.