Was cast in the role of Nurse Abigail 'Abby' Lockhart in "ER" (1994), without an audition.
One of her closest friends is her "ER" (1994) co-star, Laura Innes. Maura officiated at Laura's wedding.
Maura was added to the cast of "NewsRadio" (1995) the day before they shot the pilot.
In the "NewsRadio" (1995) episode "Presence", her character "Lisa Miller" is a math whiz who learns to play poker to win back Bill (Phil Hartman) after their boss "Jimmy James" (Stephen Root) loses Bill in an inter-station poker game. In real life, Tierney won the 2004 (Season 2) "Celebrity Poker Showdown" (2003), hosted by Dave Foley. Tierney defeated Lauren Graham at the final table. Foley, Graham and Tierney all appeared in "NewsRadio" (1995).
Played an alcoholic in Oxygen (1999) and on "ER" (1994).
Wrote an article in the spring 2001 issue of Flaunt titled, "'Rudy Giuliani' : A Fascist? You Be The Judge."
On "Last Call with Carson Daly" (2002), she stated that she and her husband Billy Morrissette were fired from a sitcom known as The Ralph Macchio Project.
On "Last Call with Carson Daly" (2002), she admitted that she was fired from the television show "Growing Pains" (1985). The show was supposed to have an episode arc in Europe, but the idea was scrapped when Kirk Cameron expressed a fear of flying.
While being interviewed on Irish chat show "Tubridy Tonight" (2004), Maura admitted that she has had Botox although she did not like the experience. (February 2009).
Undergoing surgery to remove a tumor from her breast [July 13, 2009].
Had to leave "Parenthood" (2010) after discovering she had breast cancer. Promotional items with Maura were already released by NBC to promote the show in 2009 and production had to be pushed back, because of Maura's leave. She was eventually replaced by Lauren Graham.