Stepson of Keith Morrison, NBC newscaster. Half-brother of Caitlin (b. 1981); Emily (b. 1985); Willy (b. 1987); Madeleine (b. 1989); and Marie Perry.
According to an interview, Matthew claimed that when he was filming A Night in the Life of Jimmy Reardon (1988) he had formed a star complex and would cockily ask his fellow co-stars what they planned on doing now that "they were on their way". He then said that reality settled in once the movie was released and nothing happened.
he asked that his name be removed from the Best Actor in a Comedy Emmy list. "Friends" (1994) co-stars have all agreed that they would only be nominated in supporting roles. [June 2000]
Following the May 6, 2004 airing of the "Friends" (1994) series finale, he and the rest of the show's cast were on the Jay Leno broadcast from the Central Perk set in the "Friends" (1994) studio.
He spoke the last line in the final episode of "Friends" (1994). When it's suggested that they all go out for coffee, his character Chandler says "Where?".
Behind the scenes of "Friends" (1994), Perry was very close friends with co-star Jennifer Aniston.
He is the only central cast member of "Friends" (1994) who has not been nominated for a Razzie.
Is the youngest cast member of "Friends" (1994).
His father appeared on the "Friends" (1994) episode "Friends: The One with Rachel's New Dress (#4.18)" (1998), as the father of one of Jennifer Aniston's boyfriends.
Turned down a role in Independence Day (1996). The part he was offered was eventually taken by Harry Connick Jr..
Was the Ottawa Loggers 10th selection in the 1996 RHI (Roller Hockey International) draft.
His father, John Bennett Perry, played his father in Fools Rush In (1997).
The part of Maj. Don West in Lost in Space (1998) was originally offered to him, but eventually went to "Friends" (1994) co-star Matt LeBlanc.
In season 1, episode 16 of "The West Wing" (1999), he was mentioned as a guest at a party the president was attending in L.A. He later played the character of Joe Quincy in three episodes during the fourth and fifth seasons.
Both in The Whole Nine Yards (2000) and Three to Tango (1999), his characters are asked "Are you always this nervous?". Both times the response is "yes.".
Entered a rehabilitation clinic for treatment of an undisclosed condition. [27 February 2001]
A 75 year old woman ran a stop sign and smashed into the side of Matthew's BMW. Neither party was injured. [18 April 2001]
His real-life father, John Bennett Perry, played his father when he guest-starred on the "Scrubs" (2001) episode "Scrubs: My Unicorn (#4.11)" (2004).
"Friends" (1994) castmates agree to enter themselves for consideration in the leading role catagories at the Emmys. 
"Friends" (1994) castmate Jennifer Aniston offers to be his personal trainer after he received threats from bosses Warner Brothers about his increasing weight problems 
Made his world stage debut in the West End in London alongside Minnie Driver. [May 2003]
Appeared in the top 30 of Forbes Top 100 Celebrity rich list for the first time 
His favorite NHL team is the Ottawa Senators. He often attends the playoff games in Ottawa, Canada. He attended this year's playoff games between Ottawa and Toronto Maple Leafs (2004).
Close friends with "Studio 60 on the Sunset Strip" (2006) co-star Bradley Whitford and actor Hank Azaria.
Is on the board of directors for the soon-to-be-opened Ron Clark Academy in Atlanta, Georgia. Ron Clark is a world-renowned educator who Perry depicted in the TNT original film The Ron Clark Story (2006) (TV).