When he was a child, his family moved to Villanova, PA in 1978, when his father got a job on WPVI, Channel 6.
Attended Rosemont School of the Holy Child and graduated at age 14 in 1983.
Graduated from Ithaca College with a degree from the Roy H. Park School of Communications. 
He has a niece named Caledonia, born in 1994 and a nephew named Griffin, born in 1997.
Ironically, played a vampire's victim in the movie Macabre Pair of Shorts (1996).
One of two actors to appear on both first episodes of Joss Whedon's "Buffy the Vampire Slayer" (1997) and spin-off show "Angel" (1999) (the other being Charisma Carpenter), as well as one of two actors to appear in both last episodes of the two sister shows, the other being James Marsters (Spike).
Is one of Christian Kane's best friends. They have been friends since before David became Angel on "Buffy the Vampire Slayer" (1997).
Sued by ex-landlord for allegedly trashing a house; denies the charge. [5 November 1998]
He is suing the driver of a car, Oren Kaniel, that crashed into his 1999 Mercedes-Benz on the Ventura Freeway in Los Angeles, north of Western Avenue, on Aug. 3 1999. He is seeking damages for pain and suffering, medical care, loss of earnings, repairs to his car, being deprived of his car while it was fixed, and damage to his personal property. [July 2000]
Playing the role of Angelus on "Angel" (1999) for February sweeps in 2003, Boreanaz ad libbed a lot of his lines. Co-star Amy Acker said in an interview, "I think it's great; he has so much fun playing that character. It's a lot of improvisation and taking risks. You never know what he's going to say; it changes from take to take." [January 23, 2003].
He and Christian Kane are the only two actors to appear in both the very first and last episode of "Angel" (1999).
David has a Kanji tattoo on each wrist, one means "Soul" and the other means "Destiny". His wife, Jaime Bergman has the matching tattoos. You can see them in two "Angel" (1999) episodes - "Angel: Lullaby (#3.9)" (2001) and "Angel: Orpheus (#4.15)" (2003). The tattoo makes it first appearance in "Bones: The Man in the Bear (#1.4)" (2005), at the end while he's trying to eat breakfast with Dr. Brennan.
Announced engagement to Jaime Bergman. [August 2001]
Married actress Jaime Bergman on Thanksgiving Day 2001 in a very private and familiar ceremony.
He was supposed to marry Jaime Bergman in September 2001, but, because of terrorists attacks on September 11, the wedding was postponed.
Awarded the Young Alumni award in 2001 from Ithaca College.
His wife, Jaime Bergman, gave birth to their first child, a son, Jaden Rayne. [1 May 2002]
His son, Jaden Rayne, was born on May 1st 2002 at 12.59am, weighing 8lb 9oz.
Was the original choice for the character Matt Addison in Resident Evil (2002), but turned down the part due to scheduling conflicts with his TV series "Angel" (1999).
Appeared with Kristine Sutherland (Joyce Summers), Nicholas Brendon (Xander), and Mark Lutz (Groosalugg) at the Angel and Buffy Convention held at the Brighton Centre in Brighton, England, 29 August, 2003.
Named #2 of the Top Ten Sexiest Men of the Buffy / Angel universe in a fan poll by the Buffy the Vampire Slayer fanzine (2004).
Ranked #21 in TV Guide's list of "TV's 25 Greatest Teen Idols" (23 January 2005 issue).
Was offered the opportunity to play "Bruce Wayne" in Batman Begins (2005) but turned it down.
Is very good friends with his "Bones" (2005) co-star Emily Deschanel.
According to a December, 2006, New York Times article, Boreanaz grew angry about playground bullying when he was young, and went on to become offensive end and defensive back for his Catholic high school football team. Fortunately for his fans, he decided to become an actor rather than a professional athlete.
Announced that he and wife, Jaime Bergman, are expecting their second child [March 11, 2009].
Announced that the baby he and his wife are expecting in September 2009 is a girl [July 27, 2009].
Daughter, Bardot Vita Boreanaz, born August 31, 2009. She weighed 7 lbs. 14 oz.
Admitted his infidelity with Tiger Woods mistress, Rachel Uchitel [May 4, 2010].
The sexual-harassment lawsuit, brought against him by Kristina Hagan, has been settled. His attorney was Marty Singer [March 30, 2011].