Grandson of Cliff Arquette, better known as "Charley Weaver" from "The Hollywood Squares" (1965) and Julie Harrison.
Attended Mid-City Alternative school on the corner of Adams Blvd. and Arlington Avenue in the mid 1970s. His sister, Patricia Arquette, and brother, Richmond Arquette, also attended this school.
In 1990, he managed to appear in two unsuccessful television series based on popular movies: Parenthood (1989) (in which he played the role originally played by Keanu Reeves), and The Outsiders (1983) (in which he played the role originally played by Emilio Estevez).
Owns the former booking chair from the West Hollywood Police Department which was sat in by a number of different stars when they were arrested, among them Hugh Grant. David has mentioned this to Hugh, and publicly offered to give the chair to him on "Late Night with Conan O'Brien" (1993) in October of 2003.
Was succeeded in the role of Augustus McCrae in the "Lonesome Dove" film series by Steve Zahn. He and Zahn have both appeared on episodes of "Friends" (1994).
Jennifer Aniston is the godmother of his daughter Coco. She co-starred with his wife, Courteney Cox, on "Friends" (1994).
On a 2002 episode of "WWF Raw Is War" (1997), he sat behind announcers Jerry Lawler and Jim Ross for the entire show while holding a sign reading "Former WCW Champion". He was there simply as a fan, and the announcers never acknowledged him.
On "WCW Thunder" (1998) on 4/27/00, he became the WCW Heavyweight Champion in a special tag match, pitting him and his partner Diamond Dallas Page against Jeff Jarrett and Eric Bischoff. The stipulation was that whoever got the pin would become champ, and after his involvement in previous matches, Arquette was able to pin Bischoff and win the title.
He played a character whose last name is "Geller" in Never Been Kissed (1999). His wife Courteney Cox plays "Monica Geller" on "Friends" (1994). He appeared in Buffy the Vampire Slayer (1992), the title role of which was later portrayed in the TV show of the same name by Sarah Michelle Gellar, who appeared in Scream 2 (1997) with Arquette.
Since radio host Howard Stern continually referred to his wife as "Courteney Cock" in a 2000 interview, Arquette responded by calling the King of All Media "Howard Sperm".
He is in a rock band called EAR2000.
Is the voice of Eddie Wachowski, a character in the EA Sports Big game SSX Tricky (2001) (VG) (for Playstation2, Nintendo Gamecube, Xbox).
Was considered for the role of Detective Shane Vendrell on "The Shield" (2002).
He and Robert Duvall, who preceded him in the role of Augustus McCrae, have also both shared a role with a member of the Sheen family. Duvall played Robert E. Lee in Gods and Generals (2003), a role previously played by Martin Sheen in Gettysburg (1993). Arquette played Two-Bit Matthews in the television series The Outsiders (1983), a role previously played by Emilio Estevez.
13 June 2004: birth of his daughter, named Coco Arquette.
Entered a rehabilitation program to deal with alcohol abuse and "other issues". [January 2011].
Traveled to Africa for the first time as part of "Malaria No More", to witness with his own eyes the devastation Malaria has had on several regions of Senegal. [August 2011]