Paid tribute to the late Elizabeth Taylor via Twitter, stating that Taylor's film Who's Afraid of Virginia Woolf? (1966) is her favorite movie and Taylor's portrayal of Martha her favorite movie performance (23 March 2011).
Referred to in the 1991 song "Set Adrift on Memory Bliss" by PM Dawn.
In an interview on "Late Night with Conan O'Brien" (1993), she mentioned that though she has green eyes on one magazine cover picture, her eyes were changed to blue.
She and Bruce Willis are the only two actors to have guest starred in "Friends" (1994) and win an Emmy for their performance.
Was hired by Jodie Foster to star as Paula Olsen in Nell (1994) but was let go after Foster was replaced by Michael Apted as director. Applegate was replaced by Natasha Richardson.
Chosen as one of People Magazine's, "50 Most Beautiful People, 1999"
Married longtime boyfriend Johnathon Schaech on October 20, 2001, in a small Palm Springs ceremony, attended by immediate family and friends.
Is referred to in the movie Donnie Darko (2001) by Jake Gyllenhaal's character while visiting the psychiatrist.
Co-wrote "The Penis Song" with The Sweetest Thing (2002) co-stars Cameron Diaz and Selma Blair.
Grew up near the site of the notorious 1981 Wonderland (or Four-on-the-Floor) murders involving John Holmes. She later played "Susan Launius", the sole survivor of the murders, in the movie Wonderland (2003).
While filming View from the Top (2003), she met Gwyneth Paltrow. They are now good friends.
On Friday 11 March 2005, while on stage in Chicago in the Broadway-bound revival of the 1966 musical "Sweet Charity", she broke a bone in her right foot. On Friday 25 March 2005, in Boston with Charlotte d'Amboise in the titular role, its producers officially canceled the production, announcing it would close after its last regularly scheduled try-out performance, the Sunday 27 March 2005 matinée. On Tuesday 29 March 2005, the production was officially resurrected with a revised Broadway preview and opening schedule. Although Ms. d'Amboise continued in the lead role for the first week of Broadway previews, on Monday 18 April 2005, Applegate made her Broadway debut as Charity Hope Valentine. On Wednesday 4 May 2005, the second Broadway revival of "Sweet Charity" opened officially with Ms. Applegate as its star. She has been nominated for a 2005 Tony Award for Best Actress in a Musical.
Nominated for a 2005 Drama Desk Award as Best Lead Actress in a Musical for her Performance in "Sweet Charity".
Her love of the video-game Guitar Hero (2005) (VG) gave her a two-week migraine headache. She had to go to the doctor for treatment of the headache, taking time away from her TV series. Has not played the game since [April 15, 2009].
Nominated for a 2005 Tony Award as Best Lead Actress in a Musical for her Performance in "Sweet Charity".
Won a 2005 Theatre World Award for her Performance in "Sweet Charity".
Is close friends with her former "Samantha Who?" (2007) co-star Melissa McCarthy.
Became engaged to Martyn LeNoble, having been in a relationship with him since July 2008, after he proposed to her on a beach in Palm Springs (14 February 2010).
Diagnosed with breast cancer (3 August 2008).
Chosen the most beautiful person in the world by People Magazine's, "100 Most Beautiful People, 2009".
Christina and her fiancé, Martyn LeNoble, are expecting their first child [July 21, 2010].
Applegate is one of 4 actors from the film Hall Pass (2011) to become a first-time parent the same year the film was released, along with her co-stars Owen Wilson, Jenna Fischer and Alyssa Milano.
Returned to work 4 months after giving birth to her daughter Sadie in order to begin filming "Up All Night" (2011).
Gave birth to her daughter Sadie Grace LeNoble, with fiancé Martyn LeNoble, at the Cedars-Sinai Hospital in Los Angeles, weighing in at 7lbs 8oz (27 January 2011).