Attended and graduated from Canoga Park High School, Canoga Park, California in 1974.
Met his wife Robin Dearden on the set of the show "Airwolf" (1984), (Season 3, episode "Desperate Monday"). He was playing the villain of the week, and she was his hostage (held at gunpoint).
The last name of the first Blue Ranger on "Mighty Morphin' Power Rangers" (1993) was named after him. He did various work as part of the crew (voice-overs, etc.), so the Blue Ranger's full name became Billy Cranston.
Impersonated Brad Garrett's "Everybody Loves Raymond" (1996) voice shortly after losing to him for the second year in a row at the 2004 Emmy Awards. The crowd laughed hysterically, as did Brad Garrett himself.
Was singled out by frequent "Malcolm in the Middle" (2000) director Todd Holland during his Emmy speech in 2001. Cranston had been overlooked that year, and Holland proclaimed that he would "stand up here soon." Cranston was subsequently nominated for the first-time the next year.
Directed three episodes of "Malcolm in the Middle" (2000) during its fifth season. The episodes were "Vegas," "Dirty Magazine," and "Experiment".
Produced his "Kidsmartz" safety video with his "Malcolm in the Middle" (2000) crew during one of their weeks off.
Presented the category "Outstanding Directing for a Comedy Series" at the 2004 Emmy Awards with his "Malcolm in the Middle" (2000) co-star Jane Kaczmarek. Bryan had been eligible for that category (for directing the "Malcolm in the Middle" (2000) episode "Stereo Store") but did not receive a nomination.
Always grows a beard and mustache during his "Malcolm in the Middle" (2000) hiatus.
His favorite episode of "Malcolm in the Middle" (2000) is the first season episode "Rollerskates." He spent six weeks before filming learning how to rollerskate.
Played Erik Per Sullivan's character's father on "Malcolm in the Middle" (2000), and wrote recommendation letters for his college applications.
Has run in 4 marathons, according to an IGN interview .
Honored as Grand Marshal of the 2006 Sherman Oaks, CA, Street Fair by the Chamber of Commerce for his leadership in the community and his protection of children through KidSmartz.
For his role on Breaking Bad (2008) (TV), named one of the "Eight Actors Who Turn Television into Art," in cover story of The New York Times Magazine (9/11/11).